Ibuprofen Reduces Risk of Developing Parkinson's disease

Ibuprofen Reduces Risk of Developing Parkinson's disease

A new study by Harvard School of Public Health (HSPH) researchers shows that adults who regularly take ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), have about one-third less risk of developing Parkinson’s disease than non-users.


“There is no cure for Parkinson’s disease, so the possibility that ibuprofen, an existing and relatively non-toxic drug, could help protect against the disease is captivating,”

Parkinson’s disease, a progressive nervous disease occurring generally after age 50
It is hypothesized that ibuprofen may reduce inflammation in the brain that may contribute to the disease.

In the new study, Ascherio, lead author Xiang Gao, research scientist at HSPH and associate epidemiologist in the Channing Laboratory at Brigham and Women's Hospital, and colleagues analyzed data from nearly 99,000 women enrolled in the Brigham and Women’s Hospital-based Nurses’ Health Study and over 37,000 men in the Health Professionals Follow-Up Study.

The researchers identified 291 cases (156 men and 135 women) of Parkinson’s disease during their six-year follow-up study (1998-2004 in women; 2000-2006 in men). Based on questionnaires, the researchers analyzed the patients’ use of ibuprofen (e.g. Advil, Motrin, Nuprin), aspirin or aspirin-containing products, other anti-inflammatory pain relievers (e.g., Aleve, Naprosyn), and acetaminophen (e.g., Tylenol). (Although not an NSAID, acetaminophen was included because it’s similarly used to treat pain.) Age, smoking, diet, caffeine, and other variables also were considered.

“We observed that men and women who used ibuprofen two or more times per week were about 38% less likely to develop Parkinson’s disease than those who regularly used aspirin, acetaminophen, or other NSAIDs,” Gao said. “Our findings suggest that ibuprofen could be a potential neuroprotective agent against Parkinson’s disease, however, the exact mechanism is unknown.”

These findings raise hope that a readily available, inexpensive drug could help to treat Parkinson’s disease. “Because the loss of brain cells that leads to Parkinson’s disease occurs over a decade or more, a possible explanation of our findings is that use of ibuprofen protects these cells.
If so, use of ibuprofen could help slow the disease’s progression,” Gao said.

The findings do not mean that people who already have Parkinson’s disease should begin taking ibuprofen, Ascherio added. “Although generally perceived as safe, ibuprofen can have side effects, such as increased risk of gastrointestinal bleeding. Whether this risk is compensated by a slowing of the disease progression should be investigated under rigorous supervision in a randomized clinical trial,” he said.

Support for the study was provided by the National Institutes of Health’s (NIH) National Institute of Neurological Disorders and Stroke and the Intramural Research Program of NIH’s National Institute of Environmental Health Sciences.

The study will be published online March 2, 2011, in Neurology and is scheduled to appear in the March 8, 2011, print issue.

Source –
http://www.hsph.harvard.edu

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Saturday, March 05, 2011